During 1866 Wickenburg barely lost a vote to be assigned the Arizona Territory capital. During 1895 the Atchison, Topeka & Santa Fe Railway (ATSF) reached Wickenburg and constructed a depot on Frontier Street. Wickenburg would formally incorporate as a town during 1909.
In the early drafts of the US Route System, in Arizona US Route 89 didn't extend south of Flagstaff. US Route 280 was planned to be aligned from US Route 60 (which became US Route 66) from Ashfork south to US Route 80 in Phoenix by way of Wickenburg. Planned US Route 280 can be seen passing through Wickenburg along Tegner Street and Wickenburg Way southbound towards Phoenix on the 1927 Rand McNally Highway Map of Arizona.