The community of Nipomo is located on US Route 101 in southern San Luis Obispo County. Within the community of Nipomo the original alignment of US Route 101 can be found on Thompson Avenue. Depicted below is the alignment of US Route 101 through Nipomo when it was located on Thompson Avenue as seen on the 1935 Division of Highways Map of San Luis Obispo County.
The era of State Highway Maintenance through Nipomo would begin with the 1909 First State Highway Bond Act which was approved by voters in 1910. One of the highways approved through the 1909 First State Highway Bond Act was a 481.8 mile highway originating at the City Limits of San Francisco which terminated in San Diego. This highway would ultimately come to be known in time as Legislative Route Number 2 ("LRN 2"). In 1913 the Pacific Highway was plotted as a major Auto Trail which had Nipomo along it's planned route.
Early LRN 2/American El Camino Real/Pacific Highway can be seen passing through Nipomo on the 1917 California State Automobile Association Map.
The 1924 Rand McNally Map of California shows the California Banff Bee-Line Highway co-signed with the Pacific Highway on LRN 2 through Nipomo.
As noted above US 101/LRN 2 through Nipomo can be seen aligned on Thompson Avenue on the 1935 Division of Highways Map of San Luis Obispo County.